RapamycinFungusV1, Main, Exploration, bibRecord, 000E27

Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling.

Identifieur interne : 000E27 ( Main/Exploration ); précédent : 000E26; suivant : 000E28

Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling.

Auteurs : Lin Luo ; Adam A. Wall ; Jeremy C. Yeo [Australie] ; Nicholas D. Condon [Australie] ; Suzanne J. Norwood [Australie] ; Simone Schoenwaelder [Australie] ; Kaiwen W. Chen [Australie] ; Shaun Jackson [Australie] ; Brendan J. Jenkins [Australie] ; Elizabeth L. Hartland [Australie] ; Kate Schroder [Australie] ; Brett M. Collins [Australie] ; Matthew J. Sweet [Australie] ; Jennifer L. Stow [Australie]

Source :

Nature communications [ 2041-1723 ] ; 2014.

RBID : pubmed:25022365

Descripteurs français

English descriptors

KwdEn :
- Animals (MeSH), Blotting, Western (MeSH), Enzyme-Linked Immunosorbent Assay (MeSH), Mass Spectrometry (MeSH), Mice (MeSH), Mice, Knockout (MeSH), Microscopy, Electron, Scanning (MeSH), Phosphatidylinositol 3-Kinases (genetics), Phosphatidylinositol 3-Kinases (metabolism), Protein Binding (MeSH), RAW 264.7 Cells (MeSH), Signal Transduction (genetics), Signal Transduction (physiology), TOR Serine-Threonine Kinases (genetics), TOR Serine-Threonine Kinases (metabolism), Toll-Like Receptor 4 (genetics), Toll-Like Receptor 4 (metabolism), rab GTP-Binding Proteins (genetics), rab GTP-Binding Proteins (metabolism).
MESH :
- chemical , genetics : Phosphatidylinositol 3-Kinases, TOR Serine-Threonine Kinases, Toll-Like Receptor 4, rab GTP-Binding Proteins.
- chemical , metabolism : Phosphatidylinositol 3-Kinases, TOR Serine-Threonine Kinases, Toll-Like Receptor 4, rab GTP-Binding Proteins.
- genetics : Signal Transduction.
- physiology : Signal Transduction.
- Animals, Blotting, Western, Enzyme-Linked Immunosorbent Assay, Mass Spectrometry, Mice, Mice, Knockout, Microscopy, Electron, Scanning, Protein Binding, RAW 264.7 Cells.

Abstract

Toll-like receptor 4 (TLR4) is activated by bacterial lipopolysaccharide (LPS) to mount innate immune responses. The TLR4-induced release of pro- and anti-inflammatory cytokines generates robust inflammatory responses, which must then be restrained to avoid disease. New mechanisms for the critical regulation of TLR-induced cytokine responses are still emerging. Here we find TLR4 complexes localized in LPS-induced dorsal ruffles on the surface of macrophages. We discover that the small GTPase Rab8a is enriched in these ruffles and recruits phosphatidylinositol 3-kinase (PI3Kγ) as an effector by interacting directly through its Ras-binding domain. Rab8a and PI3Kγ function to regulate Akt signalling generated by surface TLR4. Rab8a and PI3Kγ do not affect TLR4 endocytosis, but instead regulate mammalian target of rapamycin signalling as a mechanism for biasing the cytokine profile to constrain inflammation in innate immunity.

DOI: 10.1038/ncomms5407
PubMed: 25022365

Affiliations:

Australie

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000E16
to stream Main, to step Curation: 000E16

Le document en format XML

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<affiliation wicri:level="1"><nlm:affiliation>1] Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria 3004, Australia [2] Heart Research Institute & Charles Perkins Centre, The University of Sydney, Sydney, New South Wales 2006, Australia.</nlm:affiliation>
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<author><name sortKey="Jenkins, Brendan J" sort="Jenkins, Brendan J" uniqKey="Jenkins B" first="Brendan J" last="Jenkins">Brendan J. Jenkins</name>
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<author><name sortKey="Hartland, Elizabeth L" sort="Hartland, Elizabeth L" uniqKey="Hartland E" first="Elizabeth L" last="Hartland">Elizabeth L. Hartland</name>
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<author><name sortKey="Sweet, Matthew J" sort="Sweet, Matthew J" uniqKey="Sweet M" first="Matthew J" last="Sweet">Matthew J. Sweet</name>
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<term>Blotting, Western (MeSH)</term>
<term>Enzyme-Linked Immunosorbent Assay (MeSH)</term>
<term>Mass Spectrometry (MeSH)</term>
<term>Mice (MeSH)</term>
<term>Mice, Knockout (MeSH)</term>
<term>Microscopy, Electron, Scanning (MeSH)</term>
<term>Phosphatidylinositol 3-Kinases (genetics)</term>
<term>Phosphatidylinositol 3-Kinases (metabolism)</term>
<term>Protein Binding (MeSH)</term>
<term>RAW 264.7 Cells (MeSH)</term>
<term>Signal Transduction (genetics)</term>
<term>Signal Transduction (physiology)</term>
<term>TOR Serine-Threonine Kinases (genetics)</term>
<term>TOR Serine-Threonine Kinases (metabolism)</term>
<term>Toll-Like Receptor 4 (genetics)</term>
<term>Toll-Like Receptor 4 (metabolism)</term>
<term>rab GTP-Binding Proteins (genetics)</term>
<term>rab GTP-Binding Proteins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Cellules RAW 264.7 (MeSH)</term>
<term>Liaison aux protéines (MeSH)</term>
<term>Microscopie électronique à balayage (MeSH)</term>
<term>Phosphatidylinositol 3-kinases (génétique)</term>
<term>Phosphatidylinositol 3-kinases (métabolisme)</term>
<term>Protéines G rab (génétique)</term>
<term>Protéines G rab (métabolisme)</term>
<term>Récepteur de type Toll-4 (génétique)</term>
<term>Récepteur de type Toll-4 (métabolisme)</term>
<term>Souris (MeSH)</term>
<term>Souris knockout (MeSH)</term>
<term>Spectrométrie de masse (MeSH)</term>
<term>Sérine-thréonine kinases TOR (génétique)</term>
<term>Sérine-thréonine kinases TOR (métabolisme)</term>
<term>Technique de Western (MeSH)</term>
<term>Test ELISA (MeSH)</term>
<term>Transduction du signal (génétique)</term>
<term>Transduction du signal (physiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Phosphatidylinositol 3-Kinases</term>
<term>TOR Serine-Threonine Kinases</term>
<term>Toll-Like Receptor 4</term>
<term>rab GTP-Binding Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Phosphatidylinositol 3-Kinases</term>
<term>TOR Serine-Threonine Kinases</term>
<term>Toll-Like Receptor 4</term>
<term>rab GTP-Binding Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Phosphatidylinositol 3-kinases</term>
<term>Protéines G rab</term>
<term>Récepteur de type Toll-4</term>
<term>Sérine-thréonine kinases TOR</term>
<term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Phosphatidylinositol 3-kinases</term>
<term>Protéines G rab</term>
<term>Récepteur de type Toll-4</term>
<term>Sérine-thréonine kinases TOR</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Blotting, Western</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Mass Spectrometry</term>
<term>Mice</term>
<term>Mice, Knockout</term>
<term>Microscopy, Electron, Scanning</term>
<term>Protein Binding</term>
<term>RAW 264.7 Cells</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules RAW 264.7</term>
<term>Liaison aux protéines</term>
<term>Microscopie électronique à balayage</term>
<term>Souris</term>
<term>Souris knockout</term>
<term>Spectrométrie de masse</term>
<term>Technique de Western</term>
<term>Test ELISA</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Toll-like receptor 4 (TLR4) is activated by bacterial lipopolysaccharide (LPS) to mount innate immune responses. The TLR4-induced release of pro- and anti-inflammatory cytokines generates robust inflammatory responses, which must then be restrained to avoid disease. New mechanisms for the critical regulation of TLR-induced cytokine responses are still emerging. Here we find TLR4 complexes localized in LPS-induced dorsal ruffles on the surface of macrophages. We discover that the small GTPase Rab8a is enriched in these ruffles and recruits phosphatidylinositol 3-kinase (PI3Kγ) as an effector by interacting directly through its Ras-binding domain. Rab8a and PI3Kγ function to regulate Akt signalling generated by surface TLR4. Rab8a and PI3Kγ do not affect TLR4 endocytosis, but instead regulate mammalian target of rapamycin signalling as a mechanism for biasing the cytokine profile to constrain inflammation in innate immunity. </div>
</front>
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<Month>12</Month>
<Day>14</Day>
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<DateRevised><Year>2016</Year>
<Month>11</Month>
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</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2041-1723</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>5</Volume>
<PubDate><Year>2014</Year>
<Month>Jul</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>Nature communications</Title>
<ISOAbbreviation>Nat Commun</ISOAbbreviation>
</Journal>
<ArticleTitle>Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling.</ArticleTitle>
<Pagination><MedlinePgn>4407</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/ncomms5407</ELocationID>
<Abstract><AbstractText>Toll-like receptor 4 (TLR4) is activated by bacterial lipopolysaccharide (LPS) to mount innate immune responses. The TLR4-induced release of pro- and anti-inflammatory cytokines generates robust inflammatory responses, which must then be restrained to avoid disease. New mechanisms for the critical regulation of TLR-induced cytokine responses are still emerging. Here we find TLR4 complexes localized in LPS-induced dorsal ruffles on the surface of macrophages. We discover that the small GTPase Rab8a is enriched in these ruffles and recruits phosphatidylinositol 3-kinase (PI3Kγ) as an effector by interacting directly through its Ras-binding domain. Rab8a and PI3Kγ function to regulate Akt signalling generated by surface TLR4. Rab8a and PI3Kγ do not affect TLR4 endocytosis, but instead regulate mammalian target of rapamycin signalling as a mechanism for biasing the cytokine profile to constrain inflammation in innate immunity. </AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Luo</LastName>
<ForeName>Lin</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>1] Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia [2].</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wall</LastName>
<ForeName>Adam A</ForeName>
<Initials>AA</Initials>
<AffiliationInfo><Affiliation>1] Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia [2].</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yeo</LastName>
<ForeName>Jeremy C</ForeName>
<Initials>JC</Initials>
<AffiliationInfo><Affiliation>Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Condon</LastName>
<ForeName>Nicholas D</ForeName>
<Initials>ND</Initials>
<AffiliationInfo><Affiliation>Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Norwood</LastName>
<ForeName>Suzanne J</ForeName>
<Initials>SJ</Initials>
<AffiliationInfo><Affiliation>Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schoenwaelder</LastName>
<ForeName>Simone</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>1] Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria 3004, Australia [2] Heart Research Institute & Charles Perkins Centre, The University of Sydney, Sydney, New South Wales 2006, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Kaiwen W</ForeName>
<Initials>KW</Initials>
<AffiliationInfo><Affiliation>Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jackson</LastName>
<ForeName>Shaun</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>1] Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria 3004, Australia [2] Heart Research Institute & Charles Perkins Centre, The University of Sydney, Sydney, New South Wales 2006, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jenkins</LastName>
<ForeName>Brendan J</ForeName>
<Initials>BJ</Initials>
<AffiliationInfo><Affiliation>Centre for Innate Immunity and Infectious Diseases, MIMR-PHI Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Victoria 3168, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hartland</LastName>
<ForeName>Elizabeth L</ForeName>
<Initials>EL</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria 3010, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schroder</LastName>
<ForeName>Kate</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Collins</LastName>
<ForeName>Brett M</ForeName>
<Initials>BM</Initials>
<AffiliationInfo><Affiliation>Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sweet</LastName>
<ForeName>Matthew J</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo><Affiliation>Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Stow</LastName>
<ForeName>Jennifer L</ForeName>
<Initials>JL</Initials>
<AffiliationInfo><Affiliation>Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>07</Month>
<Day>15</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Nat Commun</MedlineTA>
<NlmUniqueID>101528555</NlmUniqueID>
<ISSNLinking>2041-1723</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C546061">Rab8a protein, mouse</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D051197">Toll-Like Receptor 4</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.1.-</RegistryNumber>
<NameOfSubstance UI="D019869">Phosphatidylinositol 3-Kinases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber>
<NameOfSubstance UI="D058570">TOR Serine-Threonine Kinases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.6.5.2</RegistryNumber>
<NameOfSubstance UI="D020691">rab GTP-Binding Proteins</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015153" MajorTopicYN="N">Blotting, Western</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004797" MajorTopicYN="N">Enzyme-Linked Immunosorbent Assay</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013058" MajorTopicYN="N">Mass Spectrometry</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018345" MajorTopicYN="N">Mice, Knockout</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008855" MajorTopicYN="N">Microscopy, Electron, Scanning</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019869" MajorTopicYN="N">Phosphatidylinositol 3-Kinases</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011485" MajorTopicYN="N">Protein Binding</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000067996" MajorTopicYN="N">RAW 264.7 Cells</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051197" MajorTopicYN="N">Toll-Like Receptor 4</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020691" MajorTopicYN="N">rab GTP-Binding Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year>
<Month>03</Month>
<Day>12</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2014</Year>
<Month>06</Month>
<Day>16</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2014</Year>
<Month>7</Month>
<Day>16</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2014</Year>
<Month>7</Month>
<Day>16</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2015</Year>
<Month>12</Month>
<Day>15</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">25022365</ArticleId>
<ArticleId IdType="pii">ncomms5407</ArticleId>
<ArticleId IdType="doi">10.1038/ncomms5407</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Australie</li>
</country>
</list>
<tree><noCountry><name sortKey="Luo, Lin" sort="Luo, Lin" uniqKey="Luo L" first="Lin" last="Luo">Lin Luo</name>
<name sortKey="Wall, Adam A" sort="Wall, Adam A" uniqKey="Wall A" first="Adam A" last="Wall">Adam A. Wall</name>
</noCountry>
<country name="Australie"><noRegion><name sortKey="Yeo, Jeremy C" sort="Yeo, Jeremy C" uniqKey="Yeo J" first="Jeremy C" last="Yeo">Jeremy C. Yeo</name>
</noRegion>
<name sortKey="Chen, Kaiwen W" sort="Chen, Kaiwen W" uniqKey="Chen K" first="Kaiwen W" last="Chen">Kaiwen W. Chen</name>
<name sortKey="Collins, Brett M" sort="Collins, Brett M" uniqKey="Collins B" first="Brett M" last="Collins">Brett M. Collins</name>
<name sortKey="Condon, Nicholas D" sort="Condon, Nicholas D" uniqKey="Condon N" first="Nicholas D" last="Condon">Nicholas D. Condon</name>
<name sortKey="Hartland, Elizabeth L" sort="Hartland, Elizabeth L" uniqKey="Hartland E" first="Elizabeth L" last="Hartland">Elizabeth L. Hartland</name>
<name sortKey="Jackson, Shaun" sort="Jackson, Shaun" uniqKey="Jackson S" first="Shaun" last="Jackson">Shaun Jackson</name>
<name sortKey="Jenkins, Brendan J" sort="Jenkins, Brendan J" uniqKey="Jenkins B" first="Brendan J" last="Jenkins">Brendan J. Jenkins</name>
<name sortKey="Norwood, Suzanne J" sort="Norwood, Suzanne J" uniqKey="Norwood S" first="Suzanne J" last="Norwood">Suzanne J. Norwood</name>
<name sortKey="Schoenwaelder, Simone" sort="Schoenwaelder, Simone" uniqKey="Schoenwaelder S" first="Simone" last="Schoenwaelder">Simone Schoenwaelder</name>
<name sortKey="Schroder, Kate" sort="Schroder, Kate" uniqKey="Schroder K" first="Kate" last="Schroder">Kate Schroder</name>
<name sortKey="Stow, Jennifer L" sort="Stow, Jennifer L" uniqKey="Stow J" first="Jennifer L" last="Stow">Jennifer L. Stow</name>
<name sortKey="Sweet, Matthew J" sort="Sweet, Matthew J" uniqKey="Sweet M" first="Matthew J" last="Sweet">Matthew J. Sweet</name>
</country>
</tree>
</affiliations>
</record>

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	Serveur d'exploration sur la rapamycine et les champignons
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Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling.

Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling.

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